Hearing loss with semicircular canal transection and Pseudomonas aeruginosa otitis media.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15365544.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To determine if Pseudomonas aeruginosa (PA) otitis media (OM) increases the risk of sensorineural hearing loss (SNHL) with semicircular canal transection in the guinea pig model. PA was injected transtympanically into both middle ears of pigmented guinea pigs. Saline-injected animals served as controls. Two to 4 days after injection, one horizontal semicircular canal was transected and sealed. Hearing was tested using electrocochleography before and after transection. PA-OM was induced in all PA-injected ears. Five days after semicircular canal transection, click-evoked thresholds were significantly elevated in ears with PA-OM (P = 0.00009) but not in saline-injected ears (P = 0.398). Violation of the inner ear in the presence of PA-OM is associated with increased risk of SNHL in the guinea pig. Factors unique to PA infection may be responsible for SNHL with labyrinthine injury in humans with chronic otitis media.
Medical subject headings
- Hearing Loss, Sensorineural
- Otitis Media, Suppurative
- Postoperative Complications
- Pseudomonas Infections
- Semicircular Canals