Watching the DNA repair ensemble dance.
review · Level V
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Abstract
Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes, adaptor proteins, and chromatin constituents. In this issue of Cell, Lisby et al. (2004) provide a visual glimpse into how the diverse signaling and repair machines are organized in space and time around the deadliest genetic lesions--the DNA double-strand breaks.
Medical subject headings
- Cell Nucleus
- DNA
- DNA Damage
- DNA Repair