Effect of low-level resistance on subsequent enrichment of fluoroquinolone-resistant Streptococcus pneumoniae in rabbits.
other · Level V
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Abstract
We measured the effect of low-level fluoroquinolone resistance in Streptococcus pneumoniae on the development of high-level resistance within the context of the mutant selection window. Rabbits infected with S. pneumoniae were treated with ciprofloxacin or moxifloxacin concentrations that simulated pharmacokinetics in treated humans; bacteria obtained from lungs were examined for fluoroquinolone susceptibility. Ciprofloxacin enriched resistant mutants from a wild-type strain; moxifloxacin did not. However, moxifloxacin enriched resistant mutants from a parC mutant; the drug concentration at the top of the selection window was determined. A parC resistance mutation facilitates the enrichment of high-level resistance, as was predicted by in vitro measurements.
Medical subject headings
- Anti-Infective Agents
- Drug Resistance, Bacterial
- Fluoroquinolones
- Pneumococcal Infections
- Streptococcus pneumoniae