Comment on "Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity".
editorial · Level V
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- Record sourced from PubMed, PMID 15448254.
- Also identified by PMC identifier 1410731.
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Abstract
Liu et al (Science, 304:1021-4) report that NMDA receptors containing NR2A and NR2B subunits are selectively coupled to long-term potentiation (LTP) and long-term depression (LTD) respectively. Because NR2B (but not NR2A) receptors occur outside synapses, and can be activated by glutamate spillover, this principle may underlie synaptic homeostasis.
Medical subject headings
- Long-Term Potentiation
- Long-Term Synaptic Depression
- Receptors, N-Methyl-D-Aspartate
- Synapses