Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.
Level III
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Abstract
Various bioreductive drugs that are potent hypoxic cell cytotoxins can also function as effective potentiators of radiation action when administered in vivo post irradiation. There is evidence that a contributory mechanism to this potentiation is enhanced sensitivity to the bioreductive drugs exhibited by cells that are damaged sublethally by radiation.
Medical subject headings
- Antineoplastic Agents
- Aziridines
- Indolequinones
- Indoles
- Misonidazole
- Neoplasms, Experimental
- Nitroimidazoles
- Prodrugs
- Triazines