Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 15452305.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The multidrug transporter P-glycoprotein is suspected of contributing to pharmacoresistance in temporal lobe epilepsy (TLE). To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance. They identified a common haplotype that when present in the homozygous state significantly increased the risk for pharmacoresistance.
Medical subject headings
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Anticonvulsants
- Drug Resistance, Multiple
- Epilepsy, Temporal Lobe