Topical benzydamine cream and the relief of pressure pain.

Abstract

To determine whether topical benzydamine hydrochloride 3% cream is more effective than placebo in reducing pain related to pressure areas in palliative care patients. Randomized double-blind, placebo-controlled trial. Three specialist palliative care units in the north of England, with local ethical committee approval for all sites. Hospice in-patients with pain related to pressure areas. A single application of either benzydamine hydrochloride 3% cream or placebo cream to the painful pressure area. Pain assessed using 100 mm VAS, an 11-point numerical pain score and a five-point pain relief score. There was no statistically significant difference between topical benzydamine hydrochloride 3% cream and placebo cream in reducing pain related to pressure areas in palliative care patients. This study does not demonstrate a statistically significant difference between the two treatments. However the study does provide reliable information with respect to the use of different pain measurement tools in late-stage palliative patients. It also provides information regarding the baseline characteristics of this group of patients which may be useful in the planning of any future similar studies.