The power of pumping together; deconstructing the engine of a DNA replication machine.
basic_science · Level V
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- Record sourced from PubMed, PMID 15454074.
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Abstract
The replicative DNA helicase lies at the heart of the eukaryotic replication machine, yet how it works remains puzzling. New structures of the viral replicative helicase SV40 T antigen suggest that a novel concerted mode of nucleotide binding and hydrolysis powers conformation changes and DNA unwinding.
Medical subject headings
- Antigens, Polyomavirus Transforming
- DNA
- DNA Helicases
- DNA Replication