IRS2 takes center stage in the development of type 2 diabetes.
editorial · Level V
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- Record sourced from PubMed, PMID 15467824.
- Also identified by PMC identifier 518671.
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Abstract
The etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and compensatory beta cell hyperplasia followed by islet degeneration, resulting in the eventual dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes suggests a potentially unifying molecular link underlying the initiation and progression of type 2 diabetes.
Medical subject headings
- Diabetes Mellitus, Type 2
- Phosphoproteins