Judging a virus by its cover.
Where this comes from
- Record sourced from PubMed, PMID 15467827.
- Also identified by PMC identifier 518670.
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Abstract
The production of protective neutralizing antibodies occurs quickly in some viral infections but very slowly in others. In a new study, surface glycoproteins (the targets of neutralization) of 2 different viruses were genetically switched. Analysis of the neutralizing antibody response to each of the 2 parent and recombinant viruses in infected mice revealed that the speed of neutralizing antibody induction was intrinsically dependent on the surface glycoprotein and not the rest of the virus.
Medical subject headings
- Antibodies, Viral
- Membrane Glycoproteins
- Viral Envelope Proteins