Estrogen-like compounds for ischemic neuroprotection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15472107.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-alpha or estrogen receptor-beta, exhibit enhanced neuroprotective activity in in vitro models, and are potent in protecting brain tissue from cerebral ischemia/reperfusion injury. These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection.
Medical subject headings
- Estradiol Congeners
- Neuroprotective Agents
- Reperfusion Injury
- Stroke