Translation silenced by fused pair of tRNA synthetases.
basic_science · Level V
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Abstract
In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory response.
Medical subject headings
- Amino Acyl-tRNA Synthetases
- Gene Silencing
- Protein Biosynthesis