A nuclear strike against Listeria--the evolving life of LXR.
review · Level V
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Abstract
LXRs are members of the nuclear receptor superfamily and function as master regulators of cholesterol metabolism. In the macrophage, they control cholesterol efflux and inhibit the transcription factor NF-kappaB-mediated proinflammatory responses. In this issue of Cell, discover surprising, protective functions for LXRalpha in innate immunity.
Medical subject headings
- Immunity, Innate
- Listeria
- Receptors, Cytoplasmic and Nuclear