A combined linkage-physical map of the human genome.
basic_science · Level V
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- Record sourced from PubMed, PMID 15486828.
- Also identified by PMC identifier 1182151.
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Abstract
We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N=14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.
Medical subject headings
- Chromosome Mapping
- Databases, Genetic
- Genome, Human
- Physical Chromosome Mapping
- Polymorphism, Genetic