Adverse reactions to voriconazole.
case_report · Level V
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- Record sourced from PubMed, PMID 15486850.
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Abstract
Voriconazole is a new antifungal agent effective in the treatment of invasive aspergillosis. Interpatient variation in plasma concentrations is considerable--more than 100-fold. We describe 3 patients with diverse manifestations of toxicity (e.g., hallucinations, hypoglycemia, electrolyte disturbance, and pneumonitis) possibly attributable to high voriconazole concentrations. Measurement of plasma concentrations could be helpful in optimizing voriconazole dosages.
Medical subject headings
- Antifungal Agents
- Pyrimidines
- Triazoles