Pathophysiology of parkinsonism due to hydrocephalus.
case_report · Level V
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- Record sourced from PubMed, PMID 15489399.
- Also identified by PMC identifier 1738818.
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Abstract
We report a patient with hydrocephalus who developed levodopa responsive parkinsonism and severe bradyphrenia associated with shunt malfunction and revision. Magnetic resonance imaging revealed periaqueductal edema involving medial substantia nigra. [18F]dopa positron emission tomography demonstrated reduced uptake in the caudate and putamen with relative sparing of the posterior putamen. Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease.
Medical subject headings
- Hydrocephalus
- Parkinsonian Disorders
- Postoperative Complications
- Ventriculoperitoneal Shunt