Early plasmacytoid dendritic cell changes predict plasma HIV load rebound during primary infection.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 15499547.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2=0.85; Spearman's partial rho =-0.92; P=.03). pDC counts during treatment might help predict immune replication control after interruption of HAART.
Medical subject headings
- Antiretroviral Therapy, Highly Active
- Dendritic Cells
- HIV Infections
- HIV-1