Intrathecal morphine, but not buprenorphine or pentazocine, can induce spastic paraparesis after a noninjurious interval of spinal cord ischemia in the rat.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15502059.
- Also identified by DOI 10.1213/01.ANE.0000133915.56613.D9.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this study, we sought to determine the effect of intrathecal (IT) pentazocine or buprenorphine on the neurological outcome after a short interval of spinal cord ischemia in rats. Although IT morphine (30 microg) induced spastic paraparesis after 6 min of aortic occlusion, neither pentazocine (150 microg) nor buprenorphine (4 microg) produced neurological dysfunction. Our results indicate that the effect of various opioids on the motor function after a noninjurious interval of spinal cord ischemia is opioid-specific.
Medical subject headings
- Analgesics, Opioid
- Buprenorphine
- Morphine
- Paraparesis
- Pentazocine
- Spinal Cord Ischemia