In vivo evidence of neuronal loss in the hypothalamus of narcoleptic patients.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 15505179.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A dysfunction of the orexin (hypocretin) system in the hypothalamus has recently been linked to the pathogenesis of narcolepsy. The authors used in vivo proton MR spectroscopy to assess the N-acetylaspartate (NAA) content in the hypothalamus of narcoleptic patients. Hypothalamic NAA/creatine-phosphocreatine was reduced in narcoleptic patients compared with control subjects (p < 0.01). Hypothalamic neuronal loss/damage is a central pathogenetic feature in narcolepsy.
Medical subject headings
- Atrophy
- Hypothalamus
- Narcolepsy
- Nerve Degeneration
- Neurons