Factor XIIIA (cross)links AT1 receptors to atherosclerosis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 15507203.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Angiotensin II, a small peptide hormone that plays key roles in the regulation of blood pressure, also contributes to inflammatory processes that promote the development of atherosclerosis. In this issue of Cell, AbdAlla et al. (2004) provide evidence that pathogenic actions of angiotensin II involve covalent crosslinking of angiotensin AT1 receptors by factor XIIIA transglutaminase, resulting in stable receptor dimers with enhanced signaling properties.
Medical subject headings
- Angiotensin II
- Arteriosclerosis
- Factor XIIIa
- Receptor, Angiotensin, Type 1