Variability of markers of inflammation and infection in induced sputum in children with cystic fibrosis.
prospective_cohort · Level II
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Abstract
To determine reproducibility of inflammatory marker concentrations in induced sputum from subjects with cystic fibrosis (CF), 15 nonexpectorating children, 6 to 13 years of age with mild CF lung disease, underwent 3 weekly sputum inductions with 3% saline. Neutrophil elastase concentration and bacterial cultures were reproducible. This study provides useful information for investigators designing trials of anti-inflammatory therapies in CF involving sputum induction.
Medical subject headings
- Cystic Fibrosis
- Sputum