A new immune-competent animal model of mucosally derived squamous cell carcinoma.
basic_science · Level V
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Abstract
To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA). Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 x 10(6) FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis. All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph node metastases. The FAT7 flank tumor in Fischer 344 rats is a new animal model that closely resembles the behavior of human mucosal head and neck cancer. The existence of an immune-competent, mucosally derived, and reliable animal model of SCCA that somewhat resembles human head and neck SCCA gives the opportunity to perform immune-modulating experiments on head and neck cancer in these animals. B-3.
Medical subject headings
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms