HDAC4: a corepressor controlling bone development.
basic_science · Level V
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Abstract
RUNX2 is a transcription factor with a well-characterized role in bone development. In this issue of Cell, Vega and colleagues (Vega et al., 2004) show that HDAC4 interacts with RUNX2 and impacts upon chondrocyte hypertrophy and bone formation.
Medical subject headings
- Chondrocytes
- Histone Deacetylases
- Repressor Proteins