Molecular basis of intervertebral disc degeneration.
review · Level V
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- Record sourced from PubMed, PMID 15541661.
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Abstract
This review will acquaint the reader with normal development, structure, and function of the intervertebral disc. The disc is composed of the vertebral endplate, nucleus pulposus, and annulus fibrosus. These three functional components all serve important purposes for health and function of the disc. Nutrition and biomechanics are also discussed. The molecular basis of disc degeneration is reviewed so that biologic approaches to the reversal and or treatment of disc degeneration may be better understood.
Medical subject headings
- Intervertebral Disc
- Osteoarthritis
- Spinal Diseases