Value of Hu antibody determinations in the follow-up of paraneoplastic neurologic syndromes.
retrospective_cohort · Level III
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Abstract
The long-term evolution of Hu antibody (Hu-Ab) titers in patients with paraneoplastic neurologic syndromes (PNSs) is not known. Described is the evolution of Hu-Ab titers in 35 patients with PNS with a median follow-up of 32 months (range 6 to 108 months). No correlation was observed between Hu-Ab titers and neurologic outcome, tumor evolution, or type of treatment. Serial Hu-Ab determinations are not useful for monitoring the clinical outcome of patients with PNS.
Medical subject headings
- Autoantibodies
- Autoantigens
- Nerve Tissue Proteins
- Paraneoplastic Syndromes, Nervous System
- RNA-Binding Proteins