A protein kinase associated with paired helical filaments in Alzheimer disease.
basic_science · Level V
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- Record sourced from PubMed, PMID 1557394.
- Also identified by PMC identifier 48766.
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Abstract
We have identified a protein kinase in immunoaffinity-purified preparations of paired helical filaments from brain tissue of individuals with Alzheimer disease. The kinase phosphorylates the filament proteins in vitro in a manner independent of second messenger regulation or of modulation by heparin and polyamines. Physiological concentrations of hemin, an oxidized heme porphyrin, inhibit the kinase and abolish Alz-50 immunoreactivity of the proteins. Since paired helical filaments are composed of hyperphosphorylated proteins, association of a protein kinase with the filaments provides a mechanism for abnormal processing of the proteins in disease.
Medical subject headings
- Alzheimer Disease
- Neurofibrillary Tangles
- Protein Kinases