Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure.
basic_science · Level V
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- Record sourced from PubMed, PMID 1557416.
- Also identified by PMC identifier 48809.
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Abstract
The negative regulatory domain of the c-myb protooncogene product (c-Myb) normally represses transcriptional activation by c-Myb. We show here that a leucine-zipper structure is a component of the negative regulatory domain, because its disruption markedly increases both the transactivating and transforming capacities of c-Myb. We also demonstrate that this leucine-zipper structure can interact with cellular proteins. Our results suggest that an inhibitor that suppresses transactivation binds to c-Myb through the leucine zipper and that c-Myb can be oncogenically activated by missense mutation.
Medical subject headings
- DNA-Binding Proteins
- Proto-Oncogene Proteins
- Transcriptional Activation