Robustness of the no-interference model for ordering genetic markers.
basic_science · Level V
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- Record sourced from PubMed, PMID 1557418.
- Also identified by PMC identifier 48812.
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Abstract
Under the assumption of no chromatid interference, we derive constraints on the probabilities of the different recombination patterns among m + 1 genetic loci. An application of these constraints is a proof that the ordering of the loci that maximizes the likelihood under the assumption of no interference is, in fact, a consistent estimator of the true order even when there is interference.
Medical subject headings
- Genetic Linkage
- Recombination, Genetic