PPARs in atherosclerosis: the clot thickens.
editorial · Level V
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- Record sourced from PubMed, PMID 15578084.
- Also identified by PMC identifier 529290.
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Abstract
Cardiovascular disease is the leading cause of morbidity and mortality in Western countries. Previous studies have highlighted the beneficial effects of PPARgamma activators on cardiovascular disease; however, the role of other PPAR family members in atherosclerosis is less clear. A report in this issue of the JCI expands our understanding of PPARs in vascular biology and highlights the potential use of multiple PPAR agonists to limit lipid accumulation in macrophages.
Medical subject headings
- Arteriosclerosis
- Peroxisome Proliferator-Activated Receptors