Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy.
case_report · Level V
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Abstract
Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.
Medical subject headings
- Antiretroviral Therapy, Highly Active
- DNA, Viral
- HIV Infections
- Herpesvirus 8, Human
- Immune System Diseases
- Sarcoma, Kaposi