Prevention of intraventricular hemorrhage by indomethacin in male preterm infants.

Ment, Laura R; Vohr, Betty R; Makuch, Robert W; Westerveld, Michael; Katz, Karol H; Schneider, Karen C; Duncan, Charles C; Ehrenkranz, Richard et al. · J Pediatr · 2004

prospective_cohort · Level II

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Abstract

Our multicenter Indomethacin Intraventricular Hemorrhage (IVH) Prevention Trial demonstrated a reduction of IVH in preterm infants. Analysis of our cohort by sex showed indomethacin halved the incidence of IVH, eliminated parenchymal hemorrhage, and was associated with higher verbal scores at 3 to 8 years in boys.

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