Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy.

Inder, Terrie E; Hunt, Rod W; Morley, Colin J; Coleman, Lee; Stewart, Michael; Doyle, Lex W; Jacobs, Susan E · J Pediatr · 2004

rct · Level II

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Abstract

Twenty-six infants with hypoxic-ischemic encephalopathy (HIE) were randomized to normothermia or to systemic hypothermia. The hypothermia group had less cortical gray matter signal abnormality on magnetic resonance imaging (MRI) (1/12 vs 7/14 infants in the normothermic group; P = .036), which may indicate differing regional benefit from systemic hypothermia.

Medical subject headings