Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer.

Holloway, Caroline L; Robinson, Don; Murray, Brad; Amanie, John; Butts, Charles; Smylie, Michael; Chu, Karen; McEwan, A J et al. · Radiother Oncol · 2004

prospective_cohort · Level II

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Abstract

Intensity modulated radiation therapy (IMRT) guided by PET/CT imaging with respiratory gating was employed to dose escalate in patients with non-small cell lung cancer (NSCLC), using accelerated fractionation with induction chemotherapies. One patient developed a grade 5 pneumonitis and the study was halted at 84 Gy in 35 fractions.

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