In silico fine-mapping: narrowing disease-associated loci by intergenomics.
basic_science · Level V
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Abstract
Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was created to identify intergenomic consensuses to fine map QTLs and SLs in silico and select particularly promising candidate genes for such traits. Furthermore, this approach offers an empirical evaluation of animal models for their applicability to the study of human traits. http://qtl.pzr.uni-rostock.de/qtlmix.php serrano@pzr.uni-rostock.de.
Medical subject headings
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genetic Testing
- Quantitative Trait Loci
- Sequence Alignment
- Sequence Analysis, DNA
- Software