Cocaine, social behavior, and alcohol-solution drinking in monkeys.

Crowley, T J; Mikulich, S K; Williams, E A; Zerbe, G O; Ingersoll, N C · Drug Alcohol Depend · 1992

basic_science · Level V

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Abstract

Eight group-living male monkeys received cocaine (0 to 3.0 mg/kg) individually or as a group. Cocaine suppressed social affiliative behaviors, eating, and drinking (of both alcohol and control solutions). It induced bizarre stereotypies, hypervigilance, panic-like fleeing, enhancement and then suppression of locomotion, and a seizure. Cocaine had little effect on aggressiveness or sexual behavior. Proportion of time spent lying or sitting changed significantly. Cocaine produced severe behavioral abnormality in this social setting.

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