Platelets and metastasis revisited: a novel fatty link.
review · Level V
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- Record sourced from PubMed, PMID 15599391.
- Also identified by PMC identifier 535073.
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Abstract
Platelets have long been suspected of having a role in cancer progression and metastasis that has largely been attributed to platelet-mediated enhancement of tumor cell survival, extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a tumor cell mitogen and promoter of osteolysis during bone metastasis.
Medical subject headings
- Blood Platelets
- Lysophospholipids
- Neoplasm Metastasis