Acid sensing in renal epithelial cells.
review · Level V
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- Record sourced from PubMed, PMID 15599393.
- Also identified by PMC identifier 535075.
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Abstract
The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.
Medical subject headings
- Epithelial Cells
- Kidney
- src-Family Kinases