Structural drift: a possible path to protein fold change.
basic_science · Level V
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- Record sourced from PubMed, PMID 15604105.
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Abstract
Along with their mutating sequences, protein structures change in time. Analyzing a formate dehydrogenase domain that is evolutionarily related to ferredoxin, but simultaneously contains all the structural elements of a beta-Grasp fold, we illustrate here a mechanism termed as structural drift, by which changes to a protein fold can occur. grishin@chop.swmed.edu.
Medical subject headings
- Evolution, Molecular
- Ferredoxins
- Formate Dehydrogenases
- Genetic Drift
- Models, Chemical
- Models, Molecular
- Sequence Analysis, Protein