Towards a splicing code.
review · Level V
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Abstract
A combination of experimental and bioinformatics approaches leads Burge and colleagues (Wang et al., 2004 [this issue of Cell]) to a global view of how an RNA segment may be selected or avoided in mature mRNAs due to biased distributions of exonic enhancers and silencers, a process vital for genome evolution, developmental control, and disease onset.
Medical subject headings
- Algorithms
- Computer Simulation
- RNA Splicing
- Regulatory Sequences, Ribonucleic Acid
- Silencer Elements, Transcriptional