Dopamine transporter SPECT in patients with mitochondrial disorders.
case_series · Level IV
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- Record sourced from PubMed, PMID 15608010.
- Also identified by PMC identifier 1739307.
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Abstract
Mitochondrial disorders may affect basal ganglia function. In addition, decreased activity of complex I of the mitochondrial electron transport chain has been linked to the pathogenesis of dopaminergic cell loss in Parkinson's disease. Objective : To investigate the dopaminergic system in patients with known mitochondrial disorders and complex I deficiency. Dopamine transporter density was studied in 10 female patients with mitochondrial complex I deficiency by (123)I-FP-CIT (N-beta-fluoropropyl-2beta-carbomethyl-3beta-(4-iodophenyl)-nortropane) SPECT. No differences in (123)I-FP-CIT striatal binding ratios were observed and no correlation of the degree of complex I deficiency and striatal binding ratios could be detected. These data argue against the possibility that mitochondrial complex I deficiency by itself is sufficient to elicit dopaminergic cell loss.
Medical subject headings
- Brain
- Electron Transport Complex I
- MELAS Syndrome
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- Ophthalmoplegia, Chronic Progressive External