Capillary physiology and drug delivery in central nervous system lymphomas.
case_control · Level III
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- Record sourced from PubMed, PMID 15622544.
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Abstract
To evaluate whether the chemosensitivity of primary central nervous system lymphomas to water-soluble drugs could result from improved drug delivery, we quantitatively assessed pharmacokinetic factors in seven patients. The capillary permeability surface product was found to be significantly increased in central nervous system lymphomas compared with glioblastoma multiforme, medulloblastomas, and metastases. Tumoral blood flow was significantly greater than in normal white matter. Our results suggest favorable pharmacokinetics to water- and lipid-soluble drugs in primary central nervous system lymphomas.
Medical subject headings
- Capillaries
- Central Nervous System Neoplasms
- Lymphoma
- Regional Blood Flow