Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 15623710.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotype than healthy control subjects, irrespective of the presence of AIDs. Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM.
Medical subject headings
- Autoimmune Diseases
- Genes, MHC Class I
- Genes, MHC Class II
- HLA Antigens
- HLA-D Antigens
- Myositis, Inclusion Body