Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
basic_science · Level V
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- Record sourced from PubMed, PMID 15630451.
- Also identified by PMC identifier 535797.
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Abstract
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
Medical subject headings
- Endothelial Cells
- Ischemia
- Neovascularization, Physiologic
- Platelet-Derived Growth Factor
- Stem Cells