Assessing computational tools for the discovery of transcription factor binding sites.

Tompa, Martin; Li, Nan; Bailey, Timothy L; Church, George M; De Moor, Bart; Eskin, Eleazar; Favorov, Alexander V; Frith, Martin C et al. · Nat Biotechnol · 2005

basic_science · Level V

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Abstract

The prediction of regulatory elements is a problem where computational methods offer great hope. Over the past few years, numerous tools have become available for this task. The purpose of the current assessment is twofold: to provide some guidance to users regarding the accuracy of currently available tools in various settings, and to provide a benchmark of data sets for assessing future tools.

Medical subject headings