Platelet-derived growth factor in Dupuytren's disease.
basic_science · Level V
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Abstract
This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.
Medical subject headings
- Dupuytren Contracture
- Platelet-Derived Growth Factor
Anatomy
- hand