Long-term survival in severe combined immune deficiency: the role of persistent maternal engraftment.
case_report · Level V
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Abstract
Two siblings with severe combined immune deficiency, one with maternal engraftment and detectable immunologic functions who was alive at the age of 8 years are presented. Both patients had the same JAK3 gene mutation, suggesting that maternal engraftment may result in immune competence leading to long-term survival in patients with severe combined immune deficiency.
Medical subject headings
- Immunity, Maternally-Acquired
- Severe Combined Immunodeficiency