Effects of intrathecal baclofen on lumbosacral and cortical somatosensory evoked potentials.
case_series · Level IV
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Abstract
We analyzed lumbosacral and cortical somatosensory evoked potentials in three spinal cord injury patients undergoing evaluation of intrathecal baclofen infusion for management of spasticity. The cauda equina propagating root wave (R wave) and conus medullaris postsynaptic responses (S and P waves) were analyzed before and during baclofen infusion. Baclofen abolished the concomitantly recorded H-reflex and markedly suppressed the P wave amplitude and area. The S wave amplitude and area were suppressed to a lesser degree. In contrast, there were no significant changes in cortical somatosensory evoked potentials.
Medical subject headings
- Baclofen
- Cerebral Cortex
- Evoked Potentials, Somatosensory
- Muscle Spasticity
- Spinal Cord
- Spinal Cord Injuries
Anatomy
- sacrum-coccyx