Tolerability of postexposure prophylaxis with the combination of zidovudine-lamivudine and lopinavir-ritonavir for HIV infection.

Rabaud, Christian; Burty, Christine; Grandidier, Michel; Christian, Bernard; Penalba, Christian; Béguinot, Isabelle; Jeanmaire, Henri; May, Thierry · Clin Infect Dis · 2005

prospective_cohort · Level II

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Abstract

Tolerability of the combination of zidovudine-lamivudine and lopinavir-ritonavir as postexposure prophylaxis (PEP) for human immunodeficiency virus infection was prospectively assessed. A total of 121 patients were enrolled in the study; 23 patients discontinued PEP prematurely for reasons other than adverse events. Of the other 98 patients, 58 (59%) experienced adverse effects, which led to premature PEP discontinuation in 20 cases (20%).

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