Control of DNA replication and its potential clinical exploitation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 15660109.
- Also identified by DOI 10.1038/nrc1548.
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Abstract
Multiple conserved mechanisms limit DNA replication to once per cell cycle. One vital level of control focuses on the loading of the heterohexameric ring of minichromosome maintenance proteins (MCMs) onto chromatin in the hierarchical assembly of the pre-replication complex at origins of replication. An essential role in proliferation for MCMs and their regulators makes them potentially important biomarkers for routine clinical use in cancer detection and prognosis.
Medical subject headings
- Biomarkers, Tumor
- DNA Replication
- DNA-Binding Proteins
- Neoplasms