Efavirenz intoxication due to slow hepatic metabolism.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 15668854.
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Abstract
We describe a human immunodeficiency virus-positive woman who presented with severe psychosis while she was receiving therapy with efavirenz. Her plasma efavirenz level was excessively high. Genetic investigation showed that she was homozygous for the CYP2B6 G516T allele, resulting in slow hepatic metabolism. After the dosage of efavirenz was lowered, all neuropsychiatric symptoms subsided.
Medical subject headings
- Anti-HIV Agents
- Oxazines
- Psychoses, Substance-Induced